An efficient protocol for the stereoselective construction of multisubstituted fluorine-containing alkenes. a palladium-catalyzed bisstannylation of fluorinated internal alkynes

The bisstannylation has produced the corresponding bisstannylated cis-adducts by treating various fluorinated internal alkynes with hexabutylditin under the affect of Pd[(t-BuNC).sub.2][Cl.sub.2] in THF at room temperature. These adducts are subjected to the Stille cross-coupling reaction to give the corresponding tetrasubstituted fluorine-containing alkenes with defined stereochemistry.