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Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders
- Source :
- Journal of the American Chemical Society. Nov 18, 2009, Vol. 131 Issue 45, 16336-16337
- Publication Year :
- 2009
-
Abstract
- A structure-based virtual screening campaign is performed by using the X-ray structure of the [[d(TGGGGT)].sub.4] quadruplex with the aim of detecting new and structurally diverse groove binders. Six brand new different molecular entities have interacted with the groove through NMR experiments.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 131
- Issue :
- 45
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.213334162