Divalent metal ion triggered activity of a synthetic antimicrobial in cardiolipin membranes

One member of a prototypical class of antimicrobial oligomers is used for studying pore formation in cardiolipin-rich membranes and both vesicle dye-leakage assays and small-angle X-ray scattering are used for studying bilayer remodeling. The results have shown that the presence of negative intrinsic curvature lipids is necessary for pore formation by this class of molecules.