Characterization of a tyrosine kinase-peptidase A synteny in linkage group XIII of Xiphophorus fishes (Teleostei: Poeciliidae): implications for vertebrate chromosome evolution

Spontaneous and induced tumor models have been developed to explain interspecies hybrids of Xiphophorus fishes. The models have been used to evaluate tyrosine kinase-related Xiphophorus sequences and their relation to tumorigenesis. The linkage of Xiphophorus src-related sequence and linkage group XIII described an ancestral vertebrate gene arrangement. Thus, the src gene may have evolved from chromosome duplications.