Leptin does not fully account for the satiety activity of adipose tissue-conditioned medium

Experiments were performed to characterize biologically the adipose-derived satiety activity and the leptin content of adipose-conditioned media. Findings showed that native adipose tissues are capable of improving the effects of leptin on feeding and energy balance in vivo. The satiety factor derived from adipose tissue acts by either peripheral administration or by direct delivery into the central nervous system which in return causes weight loss after repeated administration.