Cytokine-mediated PGE2 expression in human colonic fibroblasts

A study was conducted to explain the role of cytokines in human colonic fibroblasts in prostaglandin H synthase-2 messenger ribonucleic acid (PGHS-2 mRNA) and protein induction. The findings described the interleukin-1 beta's enhancement of PGHS-2 expression. Moreover, PGHS-2 and PGE synthesis were more prominent in colonic fibroblasts than other neoplastic and non-neoplastic colonic epithelial cells. These findings identify fibroblasts as cell targets for the beneficial use of non-steroidal anti-inflammatory drugs (NSAIDs) in colorectal cancer pain treatment.