Plasma glutathione S-transferase Alpha 1-1: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy

Measuring blood levels of glutathione S-transferase Alpha 1-1 (GSTA1-1) may allow physicians to diagnose many serious complications of pregnancy sooner. This enzyme is released into the bloodstream during liver damage. Two pregnancy complications that involve liver damage are preeclampsia and the HELLP syndrome. Researchers measured blood levels of GSTA1-1 and another liver enzyme called alanine aminotransferase in 274 pregnant women. GSTA1-1 levels were substantially higher than alanine aminotransferase levels in the women with preeclampsia or HELLP syndrome.