Mice expressing human but not murine beta 3-adrenergic receptors under the control of human gene regulatory elements

[Β.sub.3]-Adrenergic receptors (ARs) are expressed predominantly in adipose tissue, and [Β.sub.3]-selective agonists are effective anti-obesity drugs in rodents. Rodent and human [Β.sub.3]-ARs differ with respect to expression in white versus [...]