Iron-deficiency sensitizes mice to acute pain stimuli and formalin-induced nociception

Iron deficiency has been described asa risk factor in secondary restless legs syndrome (RLS), although it has not been investigated whether iron deficiency induces sensory symptoms in RLS patients. In this study, we established a mouse model of iron deficiency by administering a purified iron-deficient (ID) diet ( doi: 10.3945/jn.109.112557