Chronic ingestion of dietary fat is a prerequisite for inhibition of feeding by enterostatin

The consequences of enterostatin in rats that were adapted to either a high-fat (HF) or high-carbohydrate/low-fat (HC) diet and then exposed to either HF or HC diets were investigated. Results showed that chronic intake of dietary fat is needed for enterostatin action and that chronic ingestion of fat starts a postingestion metabolic, endocrine or neurochemical change that is needed for the biological response to enterostatin.