Urate uptake and lowered ATP levels in human muscle after high-intensity intermittent exercise

Seven subjects were employed in the investigation of purine exchange in exercised and rested muscles and its relation to ATP levels in muscles after intense physical activity. Results reveal that significant levels of purines are released into the blood stream after one session of sustained physical activity thereby depleting the muscle ATP stores. Further, muscles undergoing heavy exercise were also observed to extract urate from the blood.