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Differential translocation of protein kinase C isozymes by phorbol esters, EGF, and ANG II in rat liver WB cells
- Source :
- The American Journal of Physiology. April, 1998, Vol. 274 Issue 4, pC974, 9 p.
- Publication Year :
- 1998
-
Abstract
- The effects of phorbol esters, epidermal growth factor (EGF) and angiotensin (ANG) II on the translocation of the alpha, delta and epsilon isozymes of protein kinase C in rat liver epithelial cells were investigated through Western blot analysis following subcellular fractionation of treated tissues. Phorbol esters induced the highest degree of membrane translocation of the different isozymes. Although the magnitude of translocation induced by both EGF and ANG II is low, the significant translocation of the delta and epsilon isozymes is enough to explain spatially defined effects.
Details
- ISSN :
- 00029513
- Volume :
- 274
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.21093533