High exogenous concentrations of phenoxyacetic acid are crucial for a high penicillin V productivity in Penicillum chrysogenum

Glucose was utilized as a growth-limiting component for a high-penicillin-yielding strain of Penicillium chrysogenum grown in a chemically defined medium. In this study, the high production of penicillin was sustained by maintaining a high amount of phenoxyacetic acid concentration in the strain. This also reduced the loss of the pathway intermediate isopenicillin N in the extracellular medium.