Back to Search
Start Over
High mobility group protein-1 (HMG-1) is a unique activator of p53
- Source :
- Genes & Development. Feb 15, 1998, Vol. 12 Issue 4, p462, 11 p.
- Publication Year :
- 1998
-
Abstract
- Binding of p53 protein to DNA is set off by interaction with covalent and noncovalent modifiers. Identification of a factor from HeLa nuclear extracts that start up p53 CNA binding has been achieved. It was found to be a high-mobility group protein, HMG-1, and belongs to a family of much-conserved chromatin-associated nucleoproteins. Members of the family bend DNA and aid binding of some transcription factors to cognate DNA sequences. Recombinant His-tagged HMG-1 helps in p53 DNA binding in vitro and HMG-1; p53 can interact directly in vitro. HMG-1 is unique as an activator of p53.
Details
- ISSN :
- 08909369
- Volume :
- 12
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.21027916