Pharmacokinetic drug-drug interaction study of delavirdine and indinavir in healthy volunteers

Delavirdine appears to inhibit metabolism of indinavir, but does not alter absorption of the drug, when they are administered together. Delavirdine is a non-nucleoside reverse transcriptase inhibitor and indinavir is a protease inhibitor, both used in the treatment of HIV. Researchers gave the drugs to 14 healthy volunteers to determine patterns of absorption and drug interaction. Delviridine slightly lengthened the time required for indinavir levels in the blood to fall. When the drugs are used together, the dosage or dosing frequency of indinavir may be reduced.