Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers

The involvement of the splanchnic afferent nerves on the induction of anorexia by intraperitoneal administration of amylin is investigated by pretreating rats with capsaicin, a neurotoxin that destroys sensory nerves. Results reveal that amylin exerted its anorexic effects even with the destruction of splanchnic sensory nerves indicating that its effects and those of the calcitonin-gene related peptide are central. Correlation of the results with previous studies indicates that the target of amylin is the area postrema and the nucleus of the tractus solitarius.