X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin

Authors :: Gruber, Todd D.
Westler, William M.
Kiessling, Laura L.
Forest, Katrina T.
Source :: Biochemistry. Sept 22, 2009, Vol. 48 Issue 37, 9171-9173
Publication Year :: 2009
Abstract: The catalysis of the interconversion of UDP-galactopyranose and UDP-galactofuranose, a key building block for cell wall construction in Mycobacterium tuberculosis by flavoenzyme uridine 5'-diphosphate galactopyranose mutase is studied. X ray crystallography is employed to investigate the binding of flavin.

Subjects :: Enzyme binding -- Analysis
Flavin mononucleotide -- Structure
Flavin mononucleotide -- Chemical properties
Mycobacterium tuberculosis -- Physiological aspects
Mycobacterium tuberculosis -- Genetic aspects
X-ray crystallography -- Usage
Biological sciences
Chemistry

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