Total synthesis and structure-activity investigation of the marine natural product neopeltolide

Authors :: Custar, Daniel W.
Zabawa, Thomas P.
Hines, John
Crews, Craig M.
Scheidt, Karl A.
Source :: Journal of the American Chemical Society. Sept 2, 2009, Vol. 131 Issue 34, 12406-12414
Publication Year :: 2009
Abstract: The total synthesis and biological evaluation of neopeltolide and analogs are described. The biological data of the analogs have shown that alterations to either the ester side chain or the stereochemistry of the macrolide have resulted in a loss of biological activity.

Subjects :: Cancer cells -- Physiological aspects
Esters -- Structure
Esters -- Chemical properties
Macrolide antibiotics -- Structure
Macrolide antibiotics -- Chemical properties
Substitution reactions -- Analysis
Chemistry

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