Backbone and side chain dynamics of uncomplexed human adipocyte and muscle fatty acid-binding proteins

A study on the backbone and side chain mechanisms of uncomplexed human adipocyte lipid-binding protein (apo-A-LBP) and muscle fatty acid-binding proteins (apo-M-FABP) is presented. A-LBPs and M-FABPs are intracellular lipid-binding proteins that transport and store lipids. A-LBPs are found in fat cells while M-FABPs are found in skeletal muscles, the heart and the kidneys. These proteins have the same fold structure made up of 10 antiparallel beta strands and a helix-loop-helix design joining the A and B beta strands.