Noncovalent synthesis of shape-persistent cyclic hexamers from ditopic hydrazide-based supramolecular synthons and asymmetric induction of supramolecular chirality

Properly encoded recognition sites and a well-defined algorithm for intermolecular and intramolecular interactions are used for self-assembling the 120 [degree] spacer linked ditopic hydrazide-based supramolecular synthons into shape-persistent cyclic hexamers in apolar solvents. The assembly from the monomer with chiral auxiliary terminative groups has exhibited supramolecular chirality in solution, which is confirmed by concentration-dependent CD spectra.