Identification of residues lining the anthrax protective antigen channel

A study was conducted to identify the residues lining the anthrax protective antigen channel. The results reveal alternating reduction and absence of reduction of conductance in consecutive residues over two stretches. The findings provide support for the model of conversion of the prepore to a 14-stranded Beta barrel pore and fortify the foundation for future research on the mechanism of translocation by anthrax toxin.