In situ tissue engineering for tracheal reconstruction using a luminar remodeling type of artificial trachea

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2008.07.072 Byline: Tatsuo Nakamura (a), Toshihiko Sato (a), Masato Araki (a), Satoshi Ichihara (a), Akira Nakada (a), Makoto Yoshitani (a), Shin-ichi Itoi (a), Masaru Yamashita (b), Shin-ichi Kanemaru (b), Kouichi Omori (c), Yoshio Hori (a), Katsuaki Endo (d), Yuji Inada (a), Katsumi Hayakawa (a) Abbreviations: CBF, cilial beat frequency; MRI, magnetic resonance imaging; MSC, mesenchymal stem cell Abstract: After successful trials of tracheal reconstruction using mesh-type prostheses in canine models, the technique has been applied clinically to human patients since 2002. To enhance tissue regeneration, we have applied a new tissue engineering approach to this mesh-type prosthesis. Author Affiliation: (a) Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan (b) Department of Otolaryngology, Kyoto University, Kyoto, Japan (c) Department of Otolaryngology, Fukushima Medical University, Fukushima, Japan (d) Department of Physiology, Kyoto Nerve Regeneration Research Center, Kyoto, Japan Article History: Received 2 February 2008; Revised 12 May 2008; Accepted 3 July 2008 Article Note: (footnote) This work was supported partly by a Health and Labor Science Research Grant for Research on the Human Genome, and Tissue Engineering, from the Ministry of Health, Labor and Welfare of Japan.