Retinoblastoma protein recruits histone deacetylase to repress transcription

Histone deacetylase activity is ascribed to HDAC1 and HDAC2, mammalian proteins, existing in a complex with other proteins, and are implicated in transcriptional repression due to nucleosome remodelling. Rbp48, a known Rb-binding protein, is found in the deacetylase complex, and an investigation was undertaken to determine if the Rb repressor is linked to histone deacetylase activity, and results indicated its association with deacetylase activity in vivo.