Genetic modifiers of liver disease in cystic fibrosis

Authors :: Bartlett, Jaclyn R.
Friedman, Kenneth J.
Ling, Simon C.
Pace, Rhonda G.
Bell, Scott C.
Castaldo, Giuseppe
Bourke, Billy
Castellani, Carlo
Cipolli, Marco
Colombo, Carla
Colombo, John L.
Debray, Dominique
Fernandez, Adriana
Lacaille, Florence
Macek, Milan Jr.
Rowland, Marion
Salvatore, Francesco
Taylor, Christopher J.
Wainwright, Claire
Wischanski, Michael
Zemkova, Dana
Hannah, William B.
Phillips, M. James
Corey, Mary
Zielenski, Julian
Dorfman, Ruslan
Wang, Yunfei
Zou, Fei
Silverman, Lawrence M.
Wright, Fred A.
Lange, Ethan M.
Durie, Peter R.
Knowles, Michael R.
Drumm, Mitchell L.
Source :: JAMA, The Journal of the American Medical Association. Sept 9, 2009, Vol. 302 Issue 10, p1076, 8 p.
Publication Year :: 2009
Abstract: A study was conducted to evaluate whether certain gene modifiers were associated with severe liver disease in patients with cystic fibrosis (CF). Results indicated that the SERPINA1 Z allele was associated with risk of developing the disease.

Subjects :: Liver diseases -- Causes of
Liver diseases -- Genetic aspects
Cystic fibrosis -- Risk factors

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