Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture

The time-dependent changes in the extent of calcium oxalate (CaOx) monohydrate (COM) crystal binding to Madin-Darby canine kidney (MDCK) cells during their growth to confluence and during the healing of wounds made in confluent monolayers were studied. Findings revealed that, while functional MDCK monolayers are largely protected against COM crystal adherence, epithelial injury and the subsequent process of of wound healing lead to increased crystal binding.