Protein hydration dynamics and molecular mechanism of coupled water-protein fluctuations

A systematic global mapping of water motions in the hydration layer around a model protein of apomyoglobin in both native and molten globule states is reported. The results provide insight into a series of correlations of hydrating water dynamics and coupled fluctuations with local protein's chemical and structural properties which are significant for various water behaviors in the hydration layer with wide heterogeneity.