Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response

A study was conducted to examine the toxic effects of linoleic acid hydroperoxide (LoaOOH) to Saccharomyces cerevisiae using a wild-type yeast and isogenic mutants affected in known antioxidant defense systems. Results reveal the resistance of the bacteria to hydrogen peroxide upon pretreatment of LoaOOH. In addition, it was observed that the yeast's defense systems help in the direct and indirect detoxification of fatty acid hydroperoxides.