The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children

A live but attenuated influenza virus vaccine appears to be effective in children. Researchers tested the vaccine against a placebo in 288 children who received on dose and 1,314 children who received two doses 60 days apart. All doses were administered intranasally. The vaccine contained the same viral strains as are in the regular inactivated influenza vaccine. The vaccine was 93% effective in preventing influenza and was active against viral strains that were most common during the 1996-97 flu season.