Cardiorenal epinephrine kinetics: evidence for neuronal release in the human heart

The mechanism underlying the cardiorenal epinephrine release was analyzed through isotope-dilution method which was used on patients with congestive heart failure and hypertension and healthy individuals as the control variable. Results have shown that under baseline conditions, cardiac release of Epi in congestive heart patients was evident through (3H)Epi dilution. A decrease in cardiorenal fractional extractions of epinephrine was noted following neuronal blockade.