Localization of endothelin-converting enzyme-1 in human kidney

Authors :: Pupilli, C.
Romagnani, P.
Lasagni, L.
Bellini, F.
Misciglia, N.
Emoto, N.
Yanagisawa, M.
Rizzo, M.
Mannelli, M.
Serio, M.
Source :: The American Journal of Physiology. Nov, 1997, Vol. 273 Issue 5, pF749, 8 p.
Publication Year :: 1997
Abstract: The distribution of endothelin-converting-enzyme-1 (ECE-1) messenger ribonucleic acid (mRNA) and its protein in the human kidney was assessed by implementing immunochemistry and hybridization at the site. The results revealed that ECE-1 is dispersed throughout the human kidney in vascular endothelial and tubular epithelial cells. The comparison made between the manner of distribution of ECE-1 and anti-von Willebrand factor had established the endothelial mechanism of the cells studied.