Elucidating the mechanism of lipid membrane-induced IAPP fibrillogenesis and its inhibition by the red wine compound resveratrol: a synchrotron X-ray reflectivity study

X-ray reflectivity (XRR) measurements are carried out on the islet amyloid polypeptide (IAPP) at lipid interfaces, providing a molecular level characterization of the first steps of the lipid-induced fibrillation process of IAPP. The studies have shown that the polyphenolic red wine compound resveratrol has inhibited IAPP aggregation in the presence of aggregation-fostering negatively charged lipid interfaces, disclosing its potential as a drug candidate for type-II diabetes mellitus (T2DM).