Nanosized hybrid oligoamide foldamers: aromatic templates for the folding of multiple aliphatic units

Oligoamide sequences comprised of both 8-amino-2-quinolinecarboxylic acid 'Q' and 6-aminomethyl-2-pyridinecarboxylic acid 'P' are prepared. The analysis has shown that long, well-defined foldamers can be prepared stepwise and that their helical stability is continuously tuned upon controlling the ratio and sequence of P and Q monomers.