Cholecystokinin octapeptide inhibits carbohydrate but not protein intake

Experiments were performed to investigate whether levels of cholecystokinin octapeptide (CCK-8) differentially controls the termination of a carbohydrate and protein meal. In addition to CCK-8 levels and intake of pure carbohydrate and protein solutions, levels of amino acids were determined. Results indicated that regulation of a protein meal is not dependent on CCK-8 levels. On the other hand, CCK-8 could be involved in the termination of carbohydrate meal and the postprandial inhibition of further intake.