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Expression of transforming growth factor-beta 1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition

Authors :
Gilbert, Richard E.
Cox, Alison
Wu, Leonard L.
Allen, Terri J.
Hulthen, U. Lennart
Jerums, George
Cooper, Mark E.
Source :
Diabetes. March 1998, Vol. 47 Issue 3, p414, 9 p.
Publication Year :
1998

Abstract

Transforming growth factor-Β (TGF-Β) and the renin-angiotensin system (RAS) have both been implicated in the pathogenesis of glomerulosclerosis in diabetic kidney disease. However, tubulointerstitial pathology may also be an important [...]

Subjects

Subjects :
Drug therapy
Physiological aspects
Transforming growth factors -- Physiological aspects
Angiotensin converting enzyme inhibitors -- Physiological aspects
Diabetic nephropathies -- Drug therapy
ACE inhibitors -- Physiological aspects

Details

Language :
English
ISSN :
00121797
Volume :
47
Issue :
3
Database :
Gale General OneFile
Journal :
Diabetes
Publication Type :
Periodical
Accession number :
edsgcl.20385891

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