Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus

The ability of Vibrio vulnificus biotype 2, serovar E, an eel pathogen to infect humans that could become resistant to quinolone by specific mutations to gyrA and some fluoroquinolones by additional mutations in parC is demonstrated. The results indicated that in order to avoid the selection of resistant strains that are potentially pathogenic for humans, antibiotics other than quinolones must be used to treat vibriosis on farms.