Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats

Experiment was conducted to investigate the effects of dietary diosgenin (Dio), a plant-derived sapogenin, on indomethacin (Indo)-induced rats. Bile secretion, intestinal inflammation and blood chemistry were assessed in anesthetized rats three days after two subcutaneous injections of Indo given 24 h apart. dio (>80 mg.kg-1-day-1) pretreatment significantly inhibited weight and food intake decreases and intestinal inflammation. Dio significantly increased biliary cholesterol output and prevented the decreases in bile flow, bile acid output and biliary alpha-muricholic acid.