Chronic electrical stimulation increases MCT1 and lactate uptake in red and while skeletal muscle

Research was conducted to examine whether chronic stimulation of red and white rat muscles increased the concentrations of the monocarboxylate transporter MCT1. Red and white tibialis anterior (RTA and WTA, respectively) and extensor digitorum longus (EDL) muscles were chronically stimulated via the peroneal nerve for 7 days. Stimulated and contralateral muscles were analyzed for MCTI content, L-lactate uptake, lactate dehydrogenase (LDH) isoforms and muscle fiber composition. Results show that chronic muscle contraction increases MCT1 in white and red skeletal muscles.