Exogenous fructose 1,6-bisphosphate reduces K+ permeability in isolated rat hepatocytes

Experiment was conducted to study the relationship between the protective effect of fructose 1,6-bisphosphate (F-1,6-P2) against cell injury and the modifications produced in the metabolic fluxes and in the membrane permeability to K+ in isolated rat hepatocytes. The incubation of the cells in the presence of F-1,6-P2 reduced metabolic activity without affecting the ATP content which indicates a downregulation of the ATP turnover. Results strong indicate the induction of channel arrest and the associated metabolic downregulation.