The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced Methicillin resistance, encodes a phosphoglucosamine mutase

The Staphylococcus aureus femR315 gene's role in the interruption that results in reduced methicillin resistance was analyzed. The S. aureus strain COL. femR315 showed significant amino acid sequence homology with phosphoglucomutases and other similar enzymes catalyzing isomerization of hexoses and hexosamine phosphates. A staphylococcal femR315 gene can also fully complement a well-characterized glmM deficiency.