Structural characterization of a soluble amyloid [beta]-peptide oligomer

Authors :: Liping Yu
Edalji, Rohinton
Hajduk, Philip J.
Olejniczak, Edward T.
Harlan, John E.
Holzman, Thomas F.
Johnson, Robert W.
Lopez, Ana Pereda
Labkovsky, Boris
Walter, Karl
Hillen, Heinz
Barghorn, Stefan
Ebert, Ulrich
Richardson, Paul L.
Miesbauer, Laura
Solomon, Larry;
Bartley, Diane
Source :: Biochemistry. March 10, 2009, Vol. 48 Issue 9, 1870-1877
Publication Year :: 2009
Abstract: Several NMR studies are conducted to present the structural characterization of the soluble amyloid [beta]-peptide oligomers. These oligomers are shown to be highly stable and even have the capability of altering the synaptic activity.

Subjects :: Alzheimer's disease -- Research
Amyloid beta-protein -- Chemical properties
Amyloid beta-protein -- Structure
Nuclear magnetic resonance spectroscopy -- Usage
Proteins -- Structure
Proteins -- Analysis
Biological sciences
Chemistry

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