Isoprostanes as oxidant stress markers in coronary reperfusion

Urine tests for 8-epi-prostaglandin F2 alpha (8-epi-PGF2a) appear to be a useful measurement of tissue stress caused by free radical or oxidative injury. Urine levels of 8-epi-PGF2a have been shown to correspond to free radical reactions occurring as an artery is blocked and then unblocked or when smoking or drinking excessive alcohol. These effects appear to be independent of aspirin metabolism. These tests, however, are as yet impractical to use on a widespread basis.