Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3',5'-monophosphate in pregnant women with intraamniotic infection

Amniotic fluid tests for cyclic guanosine monophosphate, nitrite and nitrate might be useful for identifying pregnant women at-risk for amniotic infections. Cyclic guanosine monophosphate, nitrate, nitrite, pH and glucose levels and white blood cell count and activity were measured in 72 women in premature labor, 14 of whom had amniotic infections. Infected women had higher cyclic guanosine monophosphate, nitrate, and nitrite levels than did uninfected women. Women with these higher values also had lower glucose levels and higher white blood cell counts and activity.