The cloning of GABA(sub B) receptors

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the brain that acts on two different types of target receptor, namely, GABA (sub A) and GABA(sub B). Although the GABA(sub A) has been cloned in the 1980s, it took a decade for the GABA(sub B) receptor to be cloned when two forms of rat GABA(sub B) receptor complementary deoxyribonucleic acid were cloned using a new high-affinity antagonist for the GABA(sub B) receptor. The GABA(sub B) receptor works to open adjacent potassium channels, close voltage-gated calcium channels, and inhibit the enzyme adenylyl cyclase.