An SDF-1 Trap for Myeloid Cells Stimulates Angiogenesis

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2005.12.023 Byline: Carmen Ruiz de Almodovar (1), Aernout Luttun (1), Peter Carmeliet (1) Abstract: In this issue of Cell, examine the role of hematopoietic cells in the formation of new blood vessels. They show that organ-specific expression of vascular endothelial growth factor (VEGF) is sufficient to mobilize and recruit hematopoietic cells from the bone marrow to the blood, but retention of the proangiogenic subpopulation of hematopoietic cells in peripheral organs requires an additional factor, stromal-derived factor 1 (SDF-1). Author Affiliation: (1) The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium