Histone deacetylase activity is required for full transcriptional repression by mSin3A

Histone deacetylation plays a direct role in mSin3A-mediated transcriptional repression as demonstrated by the use of specific histone deacetylase inhibitor trapoxin in transfected cells. An increase in the transcriptional activity of an mSin3A-silenced reporter gene upon treatment in vivo with trapoxin implies that full transcriptional repressionby mSin3A requires histone deacetylation.