A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

It is possible that N-CoR, a protein of relative molecular mass 270,000 which binds to the ligand-binding area of thyroid-hormone and retinoic-acid receptors, mediates ligand-independent transcriptional repression. Researchers have identified a complex which contains this protein, the histone deacetylase mRPD3 and the Mad presumptive co-repressor mSin3. It has been found that both N-CoR and mSin3 are vital elements of a co-repressor complex which is needed for transcriptional repression in at least two classes of DNA-binding proteins.