ME-3407, new antiulcer agent, inhibits acid secretion by interfering with redistribution of H+-K+-ATPase

The antisecretory mechanisms that mediate the action of the antiulcer drug, ME-3407, were characterized in vivo in isolated gastric glands and purified H+-K+-adenosine triphosphatase (ATPase). The presence of ME-3407 in isolated gastric glands induced alterations in the incorporation of tubulovesicle-rich H+-K+-ATPase into the apical plasma membrane. The presence of ME-3407 in gastric glands also resulted in the displacement of the ezrin membrane cytoskeletal linker protein. Furthermore, the drug affected membrane recruitment events mediating parietal cell stimulation.