Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanism

The role of nitric oxide synthase (NOS) on the effects of exogenously administered agmantine on glomerular filtration rate was analyzed in isolated rat kidneys. Infusions of BHT-933 did not increase nephron filtration rate compared to the stimulatory effects of agmantine. Furthermore, agmantine exerted an opposite effect on the constitutive enzyme system involving endothelial NOS in the rat kidneys.