Short-term digestive tolerance of different doses of NUTRIOSE[R]FB, a food dextrin, in adult men

Objective:: To determine the tolerance of increasing dosages of an incompletely hydrolysed and/or incompletely absorbed food dextrin coming from wheat starch, NUTRIOSE[sup.[R]]FB, at daily levels of 10 and 15 g up to 60 and 80 g, respectively. Design:: A randomized, double-blind, multiple dose, placebo-controlled, combined crossover and parallel trial. Setting:: The metabolic ward of TNO Nutrition and Food Research. Subjects:: A total of 20 healthy men (age 31.7[plus or minus]9.1 y; BMI 24.5[plus or minus]2.9 kg/m[sup.2]). Intervention:: One group of 10 subjects consumed on top of their diet 10, 30 and 60 g of NUTRIOSE[sup.[R]]FB or maltodextrin (placebo) daily. The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. Results:: Compared with placebo, flatulence occurred more frequently over the last 6 days on 30, 60 or 80 g/day of NUTRIOSE[sup.[R]]FB (P [less than] 0.05). During the last 24 h, that is, days 6-7, of 60 and 80 g/day of NUTRIOSE[sup.[R]]FB, the frequency of flatulence was even higher (P [less than] 0.05). During the last 24 h on a daily dose of 60 g NUTRIOSE[sup.[R]]FB, the frequency of defecation decreased (P [less than] 0.05). Bloating occurred more often during the last 24 h on 80 g/day of NUTRIOSE[sup.[R]]FB (P [less than] 0.05). None of the doses of NUTRIOSE[sup.[R]]FB resulted in diarrhoea. Compared to baseline levels, breath H[sub.2] excretion, which was only measured after a week with 10 and 15 g of NUTRIOSE[sup.[R]]FB daily, increased (P [less than] 0.05). However, no difference in area under the curve was found. Conclusions:: NUTRIOSE[sup.[R]]FB is a fermentable carbohydrate and is well tolerated up to a dose of 45 g daily. Higher daily dosages (60 and 80 g) may result in flatulence, but does not result in diarrhoea. Sponsorship:: TNO Nutrition and Food Research was assigned by Roquette Fr#232;res to perform the study. European Journal of Clinical Nutrition (2004) 58, 1046-1055. doi: 10.1038/sj.ejcn.1601930 Keywords: NUTRIOSE[sup.[R]]FB, dextrin, tolerance, gastro-intestinal symptoms
Author(s): E G H M van den Heuvel [1]; D Wils [2]; W J Pasman [1]; M Bakker [1]; M-H Saniez [2]; A F M Kardinaal [1] Introduction NUTRIOSE[sup.[R]]FB is [...]