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Diastereoselective synthesis of [beta]-substituted-[alpha],[gamma]-diaminobutyric acids and pyrrolidines containing multichiral centers
- Source :
- Journal of Organic Chemistry. Feb 6, 2009, Vol. 74 Issue 3, 1252-1258
- Publication Year :
- 2009
-
Abstract
- The development of a convenient and efficient pathway for the highly diastereoselective synthesis of [beta]-substituted-[alpha][gamma]-diaminobutyric acids and pyrrolidines containing multichiral centers is reported. The synthesis of pyrrolidines with multichiral centers involved Michael-Mannich tandem reactions under mild conditions and Cu[(OTf).sub.2] or AgOTf as an activating reagent for aliphatic nitroalkenes.
- Subjects :
- Pyrrole -- Chemical properties
Pyrrole -- Structure
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 74
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.195735784