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Diastereoselective synthesis of [beta]-substituted-[alpha],[gamma]-diaminobutyric acids and pyrrolidines containing multichiral centers

Authors :
Yan Huang
Qiong Li
Tian-Liang Liu
Peng-Fei Xu
Source :
Journal of Organic Chemistry. Feb 6, 2009, Vol. 74 Issue 3, 1252-1258
Publication Year :
2009

Abstract

The development of a convenient and efficient pathway for the highly diastereoselective synthesis of [beta]-substituted-[alpha][gamma]-diaminobutyric acids and pyrrolidines containing multichiral centers is reported. The synthesis of pyrrolidines with multichiral centers involved Michael-Mannich tandem reactions under mild conditions and Cu[(OTf).sub.2] or AgOTf as an activating reagent for aliphatic nitroalkenes.

Details

Language :
English
ISSN :
00223263
Volume :
74
Issue :
3
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.195735784